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Authors
Affiliations
1 Laboratory of Pathology, Syiah Kuala University, Banda Aceh 23111, ID
2 Laboratory of Histology, Syiah Kuala University, Banda Aceh 23111, ID
3 Laboratory of Pharmacology, Syiah Kuala University, Banda Aceh 23111, ID
4 Laboratory of Parasitology, Syiah Kuala University, Banda Aceh 23111, ID
5 Laboratory of Microbiology, Syiah Kuala University, Banda Aceh 23111, ID
Source
Veterinary World, Vol 11, No 2 (2018), Pagination: 99-103
Abstract
Aim: The purpose of the present study was to determine the potential of Jatropha curcas latex in the cream formulation on CD68 immune expression (macrophages) during inflammatory phase wound healing process in mice skin.
Materials and Methods: Amount of 12 two-months-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. The mice were allotted into four groups of each, entire surface of each group wound covered by base cream control, sulfadiazine 0.1% cream, J. curcas latex cream 10% and, 15%, respectively. All experiments were performed twice a day for 3 days. The wound healing was assayed in stained histological sections in immunohistochemical of the wounds. CD68 expression was investigated under a microscope.
Results: The results showed that the cream from the 10% and 15% latex of J. curcas revealed moderate immune reaction to CD68 on wound healing.
Conclusion: We concluded that the latex cream of J. curcas possesses anti-inflammatory activity in wound healing process of mice skin.
Keywords
Anti-Inflammatory, CD68, Jatropha curcas Latex Cream, Wound Healing.
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